Recognizing the Faces of Depression Here are seven lesser-known symptoms of depression: 1. Harsh self-criticism, self-blame, feeling worthless or guilty. 2. Functioning and appearing happy, but feeling it's extremely difficult 3. Increased risky behavior like heavy substance abuse or putting oneself in dangerous situations. 4. Feeling empty, numb, or having a pessimistic and cynical outlook. 5. Ruminating on self-defeating negative thoughts, particularly following setbacks. 6. Experiencing brain