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Calcium plays a direct role in mood and nervous system regulation through its effect on serotonin. Across the menstrual cycle, estrogen rises and falls. Those shifts change how calcium is handled in the body. Higher estrogen can increase calcium loss, and in the late luteal phase serotonin also drops. That combination can worsen PMS, PMDD, and perimenopause symptoms like low mood, anxiety, irritability, bloating, and cramps. Adequate calcium intake can help support more stable neurotransmitter s
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