Genetically encoded DNA recorders convert transient biological events into stable genomic mutations, offering a means to reconstruct past cellular states. However, current approaches to log historical ...
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EDUC8 的申请将于 2026 年 3 月开放。 所有申请必须 提交 by 1 年 4 月, 2026 下午2点（太平洋标准时间） 2027年初将提供第二次申请该奖项的机会。 加州再生医学研究所 (CIRM) 设立了教育与研究培训 ...
本研究利用人类干细胞生成心脏类器官和神经元，对参与心脏发育的基因进行了系统分析。这种新方法能够识别疾病相关基因，并对特定人类细胞类型中的遗传变异进行系统分析。 科学摘要 ...
唐氏综合征（DS）由21三体综合征（TS21）引起，是导致智力障碍的最常见遗传病因(1,2)。DS的神经系统影响首先在产前发育阶段显现，表现为放射状胶质细胞（RG）神经干细胞增殖减少、皮质体积 ...
研究发育过程中心脏缺陷的遗 传原因十分困难。本研究描述了如何利用干细胞衍生的心脏类器官来探索心脏发育早期阶段的基因表达，从而识别可能与先天性心脏病相关的基因。这项研究将 ...
与哺乳动物不同，鸟类能够再生内耳毛细胞，修复听力损伤。为了将鸟类修复听力的机制应用于人类，比较鸟类和哺乳动物内耳毛细胞的叫声将有助于我们找到修复人类听力损伤的方法。
The Arctic ground squirrel (AGS, Urocitellus parryii), an extreme hibernator, exhibits remarkable resilience to stressors like hypoxia and hypothermia, making it an ideal model for studying cellular ...
This study describes methods for analysis of inner ear sensory hair progenitor cells isolated from stem-cell-derived organoids. This enables the visualization of cell and tissue morphologies within ...
Pre-implantation events in human development are difficult to study due to ethical concerns. This work utilizes a human stem-cell-based blasted model to test the genetic regulation of implantation ...
At CIRM, we aim to keep our grant funding process as simple, clear, and thorough as possible. This guide provides an overview of the process, with links to learn more and contact information for CIRM ...
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