BMJ

Prevalence of adult Huntington's disease in the UK based on diagnoses recorded in general practice records

Background and purpose The prevalence of Huntington's disease (HD) in the UK is uncertain. Recently, it has been suggested that the prevalence may be substantially greater than previously reported.
BMJ

Extended interval dosing of ocrelizumab reduces risk of developing hypogammaglobulinaemia

Introduction Disruption to clinical services, triggered by the COVID-19 pandemic, led to extended intervals between ocrelizumab treatments for some patients. Objectives To assess the rates of ...
BMJ

A nationwide survey of hypertrophic pachymeningitis in Japan

1 Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 2 Department of Neurosurgery, Kitasato University School of Medicine, ...
BMJ

Chronic inflammatory axonal polyneuropathy

Objectives Chronic inflammatory axonal polyneuropathy (CIAP) is defined on the basis of the clinical, electrophysiological and nerve biopsy findings and therapeutic responses of ‘immunotherapy ...
BMJ

Treatment of stiff person syndrome with rituximab

1 Department of Neurology, Royal Victoria Infirmary, Newcastle upon Tyne, UK 2 Department of Neurophysiology, Royal Victoria Infirmary, Newcastle upon Tyne, UK 3 Department of Rheumatology, Royal ...
BMJ

Treatment of anterior canal benign paroxysmal positional vertigo by a prolonged forced position procedure

This report presents a therapeutic procedure for refractory benign paroxysmal positional vertigo (antBPPV) of the anterior canal. Two patients with refractory antBPPV were treated by a prolonged ...
BMJ

Relapse-associated worsening in apolipoprotein E ε4 carriers with relapsing multiple sclerosis

Background In multiple sclerosis (MS), disability accrual can arise from relapse-associated worsening (RAW) and progression independent of relapse activity (PIRA). While genetic variants associated ...
BMJ

Specialist inpatient treatment for severe motor conversion disorder: a retrospective comparative study

1 National Institute for Health Research (NIHR) Biomedical Research Centre, South London & Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London, London, UK 2 Section of ...
BMJ

Depression in neurological disorders: Parkinson’s disease, multiple sclerosis, and stroke

Depression is a heterogeneous group of conditions and a clinical diagnosis without external validators. Diagnosis of depression in the setting of disorders that produce psychomotor retardation and ...
BMJ

121 Autoimmune autonomic neuropathy on the Adie spectrum: ‘Ross syndrome?’

Ross syndrome is a rare syndrome of segmental autonomic dysfunction, characterised by a triad of tonic pupils, hyporeflexia and anhidrosis. We present an atypical case of such a patient, presenting ...
BMJ

Prevalence of unruptured intracranial aneurysms: impact of different definitions – the Tromsø Study

Correspondence to Liv-Hege Johnsen, Department of Radiology, University Hospital of North Norway, Tromso, Norway; liv.hege.johnsen{at}gmail.com Background Management of incidental unruptured ...
BMJ

Appropriate use recommendations in search of reimbursement: lecanemab and the UK dilemma

Mummery et al 1 outline the recommendations for the appropriate use (AURs) of the amyloid-targeting monoclonal antibody lecanemab in clinical practice in the United Kingdom. These recommendations are ...