One main goal of anti-cancer therapies is to kill tumor cells without affecting the surrounding normal cells. Therefore, many drugs are designed to target tumor-specific antigens, which are molecules ...

When a patient undergoes an organ transplant, failure to match the donor and recipient can lead to the recipient's immune system attacking the new organ, a process triggered by a specific HLA (human ...

Human LAG-3 homodimer (with domains D1, D2, D3 and D4) binding to two separate HLA-II (MHC-II) molecules on the surface of an antigen-presenting cell (APC), imposing a distinct 38° offset angle. This ...

Using genetically engineered mice expressing a specific variant of HLA, researchers uncover the instrumental role of this protein in the development of drug eruptions. They found that when HLA binds ...

The advances in molecular biology and genomic sequencing have helped in significantly increasing the accuracy, speed, and efficiency of HLA typing. Most of the conventional methods of serological ...