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Long-Term Safety and Efficacy of Gene Therapy for Adenosine Deaminase Deficiency.

Claire Booth, Katelyn Masiuk, Konstantinos Vazouras, Augustine Fernandes, Jinhua Xu-Bayford, Beatriz Campo Fernandez, Sohini Roy, Beatrice Curio-Penny, Jordyn Arnold, Dayna Terrazas, Jack Reid, ...
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A CRISPR-engineered isogenic model of the 22q11.2 A-B syndromic deletion.

22q11.2 deletion syndrome, associated with congenital and neuropsychiatric anomalies, is the most common copy number variant (CNV)-associated syndrome. Patient-derived, induced pluripotent stem cell ...
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Loss of TJP1 disrupts gastrulation patterning and increases differentiation toward the germ cell lineage in human pluripotent stem cells.

Ivana Vasic, Ashley R G Libby, Annie Maslan, Emily A Bulger, David Zalazar, Martina Z Krakora Compagno, Aaron Streets, Kiichiro Tomoda, Shinya Yamanaka, Todd C McDevitt Biological patterning events ...
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Understanding human embryogenesis by building programmable stem cell-based models.

Stem cell-based embryo models provide an alternative system to study an elusive period of develop- ment. Programmed mouse embryo models have recently been gener- ated by activating two endogenous ...
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Molecular Signatures in Cortical Development.

The cerebral cortex, a brain structure that is responsible for higher-order cognitive functions, contains hundreds of distinct cell types distributed across dozens of anatomical and functional areas.
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Lineage-resolved atlas of the developing human cortex.

The human neocortex is composed of diverse cell types(1) that are generated during development according to spatially and temporally organized programmes initiated by neural stem cells(2-5). Despite ...
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Vax-CT 促进癌症特异性 T 记忆干细胞的形成，用于个性化癌症免疫治疗

癌症复发提出了未满足的医疗需求。 癌症疫苗很有希望，但往往缺乏长期保护。 我们将诱导T记忆干细胞（TMSCs）来增强长期免疫力。 癌症复发提出了未满足的医疗需求。 化疗和放射治疗都有副 ...
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Alexis Carlsson

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Gladstone Summer Scholars (GSS) internship program

Each summer, the Gladstone Summer Scholars (GSS) internship program recruits six rising public high school seniors to work with a mentor in our labs for 9-weeks. Interns spend 75% of their time ...
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Capitol Impact Consulting, LLC

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干细胞生物学和再生医学研究培训计划

这项研究由希望之城（City of Hope）的Joanna Filipowska博士和Rupangi Vasuvada博士设计并领导，我有幸参与其中。糖尿病的主要原因是 ...
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Evolutionary-Scale Enzymology Enables Biochemical Constant Prediction Across a Multi-Peaked Catalytic Landscape.

Duncan F Muir, Garrison P R Asper, Pascal Notin, Jacob A Posner, Debora S Marks, Michael J Keiser, Margaux M Pinney Quantitatively mapping enzyme sequence-catalysis landscapes remains a critical ...