Sirtuins are NAD +-dependent enzymes that regulate metabolism, oxidative stress, mitochondrial function, and genomic stability to influence aging and healthspan. Their tissue-specific activities have ...
Class O forkhead box transcription factors (FoxOs) have important roles in the regulation of lifespan and diseases such as diabetes and cancer. The activity of many transcription factors is controlled ...
Forkhead transcription factors of the FOXO subfamily are pivotal regulators of cancer cell fate, integrating signals from growth factors, nutrient sensors and stress pathways to control gene networks ...
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