Jones had both the highest completion percentage (69.6 percent) and yards per attempt (7.4) of his career during that stretch ...

ESPN's FPI simulation projects how the 49ers finish the 2025 season, their playoff seed, and how far San Francisco advances.

Brandon Aiyuk hasn't been a part of the San Francisco 49ers' season, and Kyle Shanahan opened up with his regret amid the ...

The last time the Colts and 49ers played was in the 2021 season, when the Colts defeated San Francisco on the road by a score ...

Could A.J. Brown be the answer to the San Francisco 49ers' wide receiver needs in 2026? We look at the trade possibilities.

An ESPN analyst believes the 49ers can make noise in the playoffs, but one fatal flaw could derail San Francisco's postseason ...

One prominent NFL insider named two teams that could potentially be interested in trading for San Francisco 49ers QB Mac ...

Monday, 8:15 p.m. EST, ESPN. BetMGM NFL odds: 49ers by 6. Against the spread: 49ers 9-5; Colts 8-6. Series record: Colts lead ...

As the Indianapolis Colts look to keep their playoff hopes alive, up next for them is a home matchup with the San Francisco ...

Despite losing to the Seattle Seahawks on Sunday in his first start since the 2020 season, Indianapolis Colts veteran ...

Two teams that could be interested? The Pittsburgh Steelers and Indianapolis Colts. The Steelers will likely be looking to ...

The 49ers' offense is about the same as 2024. The defense is worse. The special teams, though, has taken a historic leap. Is ...