For decades, scientists have been trying to develop therapeutics for people living with Alzheimer’s disease, a progressive neurodegenerative disease that is characterized by cognitive decline. Given ...

New treatments for Alzheimer disease don’t reverse cognitive symptoms, but they do significantly slow progression. Evidence suggests that earlier treatment is most effective. In his first article, ...

The search for an effective Alzheimer’s therapy has been a marathon rather than a sprint. At the end of 2022, it was reported that the anti-amyloid antibody lecanemab, which immunologically removes ...

Amyloid fibrils have been targeted in a variety of neurodegenerative diseases. The amyloid cascade hypothesis, on which many modern Alzheimer's treatments are based, presumes that these fibrils are ...

More than half of 95 centenarians had a low amyloid load and 9% had no amyloid, autopsy data showed. A third of centenarians had a high amyloid load comparable to Alzheimer's disease. Five ...

Should you receive a diagnosis of AD, many factors shape how symptoms unfold. The brain, even when under siege, retains an ...

Alzheimer’s disease is likely caused by stalled protein processing in the brain, according to a new study. The research, published today as a Reviewed Preprint in eLife, is described by editors as a ...