AUC sedimentation velocity (SV) has a longstanding reputation as being the gold standard for the matrix free quantification of aggregates in biopharmaceuticals. The continuous c(S) distribution ...

This is a preview. Log in through your library . Abstract In the evaluation of sedimentation equilibrium data for polydisperse nonideal solutions, extrapolation procedures are required for the ...

IT has been highly desirable to develop a simple device everywhere available for accurately measuring sedimentation equilibrium of particles of all sizes from the smallest molecules in solution to the ...

A fundamental aspect of the thermodynamic characterization of macromolecular complexes is the determination of the component stoichiometry. There are a number of approaches that may be employed in ...

The terminal fragment obtained by hydrolysis with ribonuclease T$_{1}$ of the ribonucleic acid from the bacteriophage Qβ has been isolated and purified. The results of chemical and enzymatic ...

Protein-protein interactions are intensively studied, not only to gain understanding of cellular function, but also for pharmaceutical development. In vitro, such complexes may be difficult to ...