A week after seizing control of the AFC South with a shootout victory over the Seattle Seahawks 38-35, the Tampa Bay Buccaneers will face another stiff test when they battle the NFC West-leading San Francisco 49ers (+3).

The NFL is once again in London on Sunday, as the Denver Broncos take on the New York Jets in what could be a high-scoring affair. Denver is favored by 7.5 poin

Could Sam Darnold be a fantasy sleeper? Can the Chiefs' defense stop the Lions' play-action? Here's last-minute intel for Week 6.

We're only one game into Week 6, but some managers may already be scrambling for late-week waiver-wire adds. Injuries continue to be problematic, and we've waded into bye-week season.

Now, SportsLine's NFL DFS Optimizer has turned its attention to Sunday's 2025 NFL Week 6 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.

Here's everything you need to know for Week 6 NFL games. Which teams will win, who are the X factors, and which storylines matter most?

Nothing like a trade to throw some spice into the middle of an NFL season.

Tight end waiver wire suggestions are available here, to help you make the best calls regarding your NFL fantasy roster heading into Week 6. See the list below for potential fantasy football targets you might be able to grab off of the waiver wire this week. Check out the full NFL schedule on FOX Sports!

Heading into week six, several superstars are sidelined with injuries. Lamar Jackson, Brock Purdy, and Brock Bowers are officially out on Sunday.