DFS millionaire Mike McClure shares his top daily fantasy football picks and lineup advice for Philadelphia vs. New York on 'Thursday Night Football'

NFL Week 6 announcers, channels, streaming information, times for all 15 games on the NFL Week 6 schedule this week. Who is announcing each game?

Week 5 of the 2025-26 NFL regular season officially gets underway on Thursday, October 2, with a Thursday Night Football primetime clash featuring the NFC West rival San Francisco 49ers and Los Angeles Rams at SoFi Stadium.

Browns vs. Steelers (-5.5), Chargers vs. Dolphins (+4.5) and Titans vs. Raiders (-4) are some other games with a line more than a field goal to consider for NFL survivor picks. Before finalizing any Week 6 NFL survivor picks, see which team the red-hot SportsLine Projection Model just went all-in on.

While much of the nation's midsection should have great weather, that's not the case in parts of the East and West. Here are the games that could be impacted.

The Minnesota Vikings and Cleveland Browns face off in London in the NFL's international game in Week 5. Here are the rest of the games this season.

When the 2025 NFL schedule came out in May, the Cleveland Browns should have filed a protest and asked the league to redo Week 6, because the Browns have been hit with a brutal scheduling quirk that only one other team in NFL history has ever had to face.