SportsLine's top NFL experts reveal their NFL picks, NFL predictions, NFL betting tips and NFL best bets for Week 6

The Arizona Cardinals (2-3) carry a three-game losing streak into a matchup against the Indianapolis Colts (4-1) on Sunday, October 12, 2025 at Lucas Oil Stadium.

It's only a month into the season, but the Browns are allowing just 70.3 rushing yards per game.

If ever there was team and time to get your mojo back, Cincinnati is that for the Packers this week.

Despite the bye week, the Packers still listed 14 players on the first injury report, including 11 who were limited or did not practice on Wednesday.