One main goal of anti-cancer therapies is to kill tumor cells without affecting the surrounding normal cells. Therefore, many drugs are designed to target tumor-specific antigens, which are molecules ...

Human LAG-3 homodimer (with domains D1, D2, D3 and D4) binding to two separate HLA-II (MHC-II) molecules on the surface of an antigen-presenting cell (APC), imposing a distinct 38° offset angle. This ...

Using genetically engineered mice expressing a specific variant of HLA, researchers uncover the instrumental role of this protein in the development of drug eruptions. They found that when HLA binds ...

Cancer immunotherapy has revolutionized treatment for patients, whereby the body's own immune system is harnessed to destroy cancer cells. Typically, several molecules restrain the ability of T cells ...