The medical profession is in the midst of losing an arms race. Bacterial antibiotic resistance doesn't just threaten our ability to treat infection but our ability to carry out any treatment where ...

Mycobacteria, notably Mycobacterium tuberculosis, employ active efflux systems to export antibiotics and reduce intracellular drug concentrations, thereby contributing to both intrinsic tolerance and ...

Tuberculosis is the world's leading infectious cause of death, killing more than one million people each year. When the antibiotic bedaquiline was introduced in 2012, it was the first new tuberculosis ...

Efflux pumps in Gram-negative bacteria actively export antibiotics out of the cell, and their overexpression can confer multidrug resistance. Two new studies explore the effect of the overexpression ...

Different types of efflux pump proteins might have evolved independently, instead of divergently as previously thought. This could yield insights in mediating antibiotic resistance. Different types of ...

Using nuclear magnetic resonance (NMR) spectroscopy, chemists have discovered how the structure of E. coli’s EmrE efflux pump—a transporter that can pump toxic molecules like antibiotics out of ...

The MarketWatch News Department was not involved in the creation of this content. TAXIS Pharmaceuticals has received an FDA QIDP designation for TXA14007, its investigational efflux pump inhibitor ...

Improper use of antibiotics makes it easier for drug-resistant strains of bacteria to arise. But as even drug-sensitive bacteria find loopholes, the problem might be even more dire than once thought.

Scientists at the University of Cambridge have uncovered the final piece in the jigsaw revealing the structure of ‘efflux pumps’, which allow Salmonella and other disease-causing bacteria to develop ...

Researchers have used a combination of genetic manipulation and protein structural analysis to determine how the position of 'bulky' amino acids influences the ability of efflux pump inhibitors to ...

image: The inhibitor-binding site of the wild-type MexB pump. (a) The crystal structure of the inhibitor ABI-PP bound to the MexB trimer. Three MexB monomers are shown in green, blue, and red, ...