Peyton Manning won Most Valuable Player the last time Indy started 5-1, and the Colts advanced to Super Bowl XLIV.

Best plays from Indianapolis Colts quarterback Daniel Jones' three touchdown game vs. the Arizona Cardinals during Week 6 of the 2025 NFL season.

There are times things get a little more complicated — and difficult — than expected. Like when the Indianapolis Colts lost Anthony Richardson Sr. in pre-game warm-ups Sunday at Lucas Oil Stadium. The backup quarterback fractured an orbital bone in an eye when he was working with a resistance band.

Indianapolis Colts quarterback Daniel Jones (17) warms up Sunday, Oct. 12, 2025, ahead of the game against the Arizona Cardinals at Lucas Oil Stadium in Indianapolis. / Mykal McEldowney/IndyStar / USA TODAY NETWORK via Imagn Images

Indianapolis Colts running back Jonathan Taylor's best plays from his 137-yard game vs. the Arizona Cardinals during Week 6 of the 2025 NFL season.

The Colts had a lot of potent offenses during the Peyton Manning era, but none of them got off to the kind of start that the 2025 edition of the team has enjoyed this fall.

It may feel redundant, but Taylor was once again the best player on the field in the Indianapolis Colts’ 31-27 Week 6 win against the Arizona Cardinals . The Colts running back finished the game with 21 carries for 123 rushing yards and a touchdown, his third game of the season with 100+ rushing yards.

But the reality is that the 4-1 Indianapolis Colts are a team to watch in the fall of 2025. They are coming off a dominant 40-6 win over the Las Vegas Raiders. Their only loss this season came from the Los Angeles Rams, who defeated them 27-20 in Week 4. Aside from that one hiccup, everything has been going Indy's way.

An NFL cheerleader was just surprised with a very special on-field wedding proposal during the Colts-Cardinals game on Sunday, Oct. 12.

Colts cornerback Charvarius Ward is out vs. the Arizona Cardinals due to a concussion suffered in pregame warmups

In the Arizona Cardinals ' 31-27 loss to the Indianapolis Colts, 18 players participated in at least one of the 73 offensive snaps. Six played every snap, while tight end Trey McBride missed seven. Travis Vokolek,