Signal transduction comprises the processes by which cells sense extracellular cues, convert them into intracellular messages and elicit appropriate responses, often culminating in changes in gene ...

Cell migration is orchestrated by signal transduction networks that translate extracellular cues into coordinated intracellular responses. Directed migration depends on the establishment of front–back ...

Activating the GPR133 receptor with a small molecule can rebuild bone from within, offering a new direction for osteoporosis ...

Lentiviral transduction is a popular delivery platform for applications such as CAR-T cell engineering or CRISPR-Cas9 gene editing, as it can transduce both dividing and non-dividing cells and ...

T cell activation—the process by which these key immune defenders recognize threats and mobilize against them—depends on exquisitely timed molecular signals. Now researchers have captured one of the ...

A newly developed therapy inspired by bacteria residing within tumors offers a different way to combat cancer by targeting ...

Macrophages use cell‑volume changes to sense danger, reprogram gene expression, and heighten inflammatory and antiviral ...

Gene expression patterns in the inner ear put an old question about structures called kinocilia back in motion.

Researchers at the University of Illinois Chicago have developed an anti-cancer therapy inspired by bacteria found in cancer tumors. When tested in combination with radiation in animal models of ...

Edited by: James Kling P.A. Hoodless, T. Haerry, S. Abdollah, M. Stapleton, M.B. O'Connor, L. Attisano, J.L. Wrana, "MADR1, a MAD-related protein that functions in ...