The San Francisco 49ers upset the Philadelphia Eagles with a remarkable defensive effort and a come-from-behind win.

Visit ESPN for San Francisco 49ers live scores, video highlights, and latest news. Find standings and the full 2025 season schedule.

It's over at Lumen Field for real this time. The Seattle Seahawks blew out the San Francisco 49ers 41-6 at Lumen Field and earned a trip to the NFC championship game. Meanwhile, the 49ers will try and ...

The Los Angeles Rams are set to acquire an All-Pro in a trade, and it puts more pressure on the San Francisco 49ers to be ...

Visit ESPN for Charlotte 49ers live scores, video highlights, and latest news. Find standings and the full 2025-26 season schedule.

San Francisco 49ers DL C.J. West sacks Seattle Seahawks QB Sam Darnold for an 8-yard loss during the NFC Divisional Round of the 2025 NFL season. San Francisco 49ers K Eddy Piñeiro made a 56-yard ...

Watch the top highlights of San Francisco 49ers QB Brock Purdy from the 2025 NFL season. Watch the San Francisco 49ers top 10 plays from the 2025 NFL season. Watch the top highlights of San Francisco ...

With the NFL Scouting Combine complete in Indianapolis, analysts are updating their 2026 NFL mock drafts based on workout data and team needs. A clear theme has emerged for the 49ers: add an offensive ...