Nancy was last seen by Annie Guthrie’s husband when he dropped her off at her home in Tucson, Arizona, on Saturday night.

Nancy Guthrie was taken from her home early Sunday, authorities said.

NBC "Today" show co-host Savannah Guthrie appeared in a video shared on Instagram and addressed her possible captor.

Investigators searching for Nancy Guthrie have encountered several key challenges in the days since the 84-year-old mother of “Today” anchor Savannah Guthrie went missing, suspected of being taken from her home.

Sheriff Chris Nanos leads Nancy Guthrie investigation with 50 years law enforcement experience. The Pima County sheriff's career spans violent crimes to drugs.

Jennifer Coffindaffer, who worked as an FBI special agent for 25 years, has questioned the timing of an alleged ransom note.

"Nancy and Savannah have both contributed so much to the Tucson community," Sally Shamrell, the Guthries' family friend of over 30 years, told CBS News.

It has been nearly 72 hours since the 84-year-old mother of "Today" cohost Savannah Guthrie went missing from her Arizona home.

"Today" show co-host Savannah Guthrie's mother has been missing since overnight on Jan. 31. Here are updates on Nancy Guthrie's disappearance.

Savannah Guthrie said she and her family were aware of reports of a ransom note and that they are "ready to talk."